Screening of at least six different fragments obtained from the C terminal section of hGH has shown that fragment 176-191 is the most effective synthetic derivative of hGH for decreasing blood sugar levels. The C terminal end of hGH principally has been observed to bring about hypoglycemic (low blood sugar) levels in mice’s bodies. The results suggest that there are secondary pathways involved in energy homeostasis that are capable of maintaining fat reserve in lean mice by overriding ADRB3 pathway. Interestingly, the peptide mediates weight reduction only in obese mice but not in lean mice during the same span of treatment. Studies have shown treatment of fragment 176-191 causes up to 50% weight reduction in obese mice over three weeks. Genetically modified mice that lack ADRB3 are resistant to the effect of hGH / fragment 176-191. Agonist activity of the fragment upon interaction with ADRB3 directly enhances fat burning in adipose tissue and triggers thermogenesis in skeletal muscle. The fat-burning action of Fragment 176-191 peptide is brought about by increasing the production of beta-3 adrenergic receptors (3-AR or ADRB3). Reconstitution: Required Physiological effects of Frag 176-191 Sequence: Tyr-Leu-Arg-Ile-Val-Gin-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe Hence the peptide can be used for anti-obesity treatments. Extensive animal studies have shown that the synthetic fragment enhances the lipolytic effects of hGH without inducing the same side effects. Human growth hormone (hGH) treatment has several adverse effects on the body, such as the suppression of carbohydrate metabolism, altered sensitivity towards insulin, the promotion of long bone growth, and heightened insulin-like growth factor-1(GF-1) levels. Developing these kind of habits will not only allow you to lose fat while using the product, but also keep it off afterwards.Fragment 176-191 peptide is a short segment of human growth hormone (hGH) and is sometimes referred to as the “lipolytic fragment.” The name was coined due to research on animal systems which has proven that Fragment 176-191 enhances fat metabolism in genetically engineered obese mice. For women this is about 1500-2000 calories and for males this is about 2500-3000 calories, depending on the level of activity (those who exercise would obviously be closer to the higher value).įurthermore, to obtain the best results possible and most amount of fat loss from HGH Fragment 176-191 you should be following a diet which is high in protein, moderate in fat and low in carbohydrates, in addition to performing cardio exercise as often as possible. This means that each day you are eating less calories than the energy your body is expending (so your body then has to burn stored fat for energy). Night time injection: Have your last meal of the day at least 3 hours before going to bed and try to make it a meal high in protein, low in fat and low in carbohydrates (a good example would be some kind of meat or fish along with salad/vegetables).įollowing either one of the above routines will ensure your body best utilizes the fat burning effects of HGH Fragment 176-191 as you will either be burning fat all morning, particularly during your cardio exercise, or you will be experiencing significant fat loss all night while you sleep.įor fat loss to occur with any kind of weight loss supplement, a calorie deficit needs to be present. When you do eat your first meal try to make it high in protein, low fat and low carbohydrates. Morning injection: Inject first thing in the morning, do some cardio exercise, then wait several hours before eating breakfast. Your results will be much more significant if you follow the following principles: Since HGH Fragment 176-191 works by releasing stored fat into the blood for usage as energy, it therefore makes sense to not consume calories around the time of your injection, since the body will more than likely preferably use them over the fat released by the peptide. For those whose budget allows it, the dosage can be increased to 1 x 500mcg injection per day of 2 x 250mcg injections per day. If you have used 3ml of water for mixing then 250mcg = 0.375ml (or 37.5 units).ġ x 250mcg per day, taken either prior to exercise (cardio) or at night time before bed. If you have used 2ml of water for mixing then 250mcg = 0.25ml (or 25 units). Injections per vial: 8 x 250mcg injectionsĪmount to Inject: If you have used 1ml of water for mixing then a 250mcg dosage = 0.125ml (or 12.5 units on Insulin Syringe).
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